Senior Scientist I, Cell Therapy Discovery

AstraZeneca

Phd in immunology or cell biology
Human t-cell isolation and culture
Lentiviral transduction moi optimization
You will own key assays and workflows for CAR design, T-cell engineering, and in vitro functional characterization

Job Summary

  • You will own key assays and workflows for CAR design, T-cell engineering, and in vitro functional characterization.
  • The role requires applying a rigorous, data-driven approach to experimental design, mechanism-of-action studies, and decision-making.
  • You will drive alignment with other teams including Pharmacology & Toxicology, CMC, translational science, and clinical functions.

Matching Summary

You will own key assays and workflows for CAR design, T-cell engineering, and in vitro functional characterization.

Skills & Requirements

Must-have

  • PhD in immunology or cell biology
  • Human T-cell isolation and culture
  • Lentiviral transduction MOI optimization
  • Flow cytometry panel design and analysis
  • Functional assays including target killing
  • PCR/qPCR and amplicon NGS prep

Nice-to-have

  • Experience with armored or logic-gated CARs
  • Familiarity with AML disease models
  • Scale-up evaluations for gene-modified products
  • Mentoring junior colleagues
  • Cross-functional collaboration skills

Key Requirements

  • PhD in immunology, cell biology, or related field
  • MS with 2-3+ years demonstrated impact in cell therapy discovery
  • Biosafety level 2 practices compliance
  • Animal ethics (IACUC) awareness
  • Research GxP awareness and data integrity standards

Work Rights

Not specified

Tailored Resume

Cover Letter