Principal Scientist, Chemical Biology - Discovery Chemistry

Johnson & Johnson UK

Spring House, Pennsylvania, United States of America
$117,000 - $201,250; bonus eligibility; comprehens...
Onsite
Organic synthesis
Chemical biology expertise
Design and synthesis of chemical biology tools
Drive and direct chemical biology functions for drug discovery projects, working in concert with partners in medicinal chemistry, chemoproteomics, disease area biology, and other key functions

Job Summary

  • Drive and direct chemical biology functions for drug discovery projects, working in concert with partners in medicinal chemistry, chemoproteomics, disease area biology, and other key functions.
  • Independently design and synthesize chemical biology tools, including photoaffinity and photocatalytic proximity labeling probes, and supervise synthetic chemistry activities at contract research organizations (CROs).
  • Forge a robust relationship with the Chemoproteomics team to design, propose, and implement chemical biology strategies and workstreams to best align with Therapeutics Discovery overall goals.

Matching Summary

Drive and direct chemical biology functions for drug discovery projects, working in concert with partners in medicinal chemistry, chemoproteomics, disease area biology, and other key functions.

Salary

$117,000 - $201,250; Bonus eligibility; Comprehensive benefits package

Skills & Requirements

Must-have

  • organic synthesis
  • chemical biology expertise
  • design and synthesis of chemical biology tools
  • photoaffinity and photocatalytic proximity labeling probes
  • activity-based protein profiling
  • photoaffinity labeling
  • cellular thermal shift assay

Nice-to-have

  • collaboration with discovery teams
  • scientific contributions
  • publication record
  • presentation at conferences
  • biopharmaceutical industry experience
  • targeted protein degradation strategies

Key Requirements

  • PhD in Organic Chemistry, Medicinal Chemistry, or Chemical Biology
  • 5+ years post-PhD experience in Chemical Biology
  • Structure-Activity Relationship (SAR)-driven design and synthesis
  • chemical biology and chemoproteomics methods
  • target identification from phenotypic screens
  • target engagement in cells or lysate
  • covalent inhibitor selectivity profiling
  • binding site identification
  • small-molecule mechanism of action elucidation
  • peer-reviewed first-author publications
  • presentations at major conferences
  • latest advances in synthetic chemistry and chemical biology
  • succeed within a matrix environment

Work Rights

Not specified

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