Principal Scientist, Adpkd Biology Lead (renal Research)

Novartis UK

Cambridge, MA, USA
Base: $108,500-$201,500 (ps i) / $126,000-$234,000...
Onsite
Adpkd disease biology expertise
Advanced 3d kidney organoid models
Target identification and validation
The Principal Scientist will shape and execute the ADPKD discovery biology strategy across a portfolio of preclinical programs to develop transformative therapies

Job Summary

  • The Principal Scientist will shape and execute the ADPKD discovery biology strategy across a portfolio of preclinical programs to develop transformative therapies.
  • This role requires translating insights from human genetics into differentiated target hypotheses and leading validation in advanced 3D model systems.
  • Candidates will deliver decision-grade biology packages to enable robust go/no-go decisions and progression to clinical candidate selection.

Matching Summary

The Principal Scientist will shape and execute the ADPKD discovery biology strategy across a portfolio of preclinical programs to develop transformative therapies.

Salary

Base: $108,500-$201,500 (PS I) / $126,000-$234,000 (PS II); Bonus/Equity: Performance-based cash incentive and annual equity awards eligible; Benefits: Comprehensive health, life, disability, 401(k), and generous time off package.

Skills & Requirements

Must-have

  • ADPKD disease biology expertise
  • Advanced 3D kidney organoid models
  • Target identification and validation
  • Mechanism of action studies
  • Drug discovery portfolio leadership

Nice-to-have

  • Single-cell omics data analysis
  • Emerging therapeutic partnership opportunities
  • Mentoring high-performing scientific teams
  • Complex renal cell platform proficiency

Key Requirements

  • PhD in nephrology or related discipline
  • 8-10+ years postdoctoral/industry experience
  • Meaningful drug discovery experience
  • Deep expertise in renal cystogenesis pathophysiology

Work Rights

Not specified

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