Principal Downstream Scientist – Mrna Purification
GSK
United States
Base: $115,500 to $192,500; bonus/equity: annual b...
Mrna purification process development
Large biomolecules purification
Affinity capture
Design, execute, and analyze experiments to develop and optimize mRNA purification processes, ensuring scalability and phase-appropriateness for clinical manufacturing
Job Summary
Design, execute, and analyze experiments to develop and optimize mRNA purification processes, ensuring scalability and phase-appropriateness for clinical manufacturing.
Collaborate with global teams, including analytical R&D, GMP, and process development colleagues, to drive innovative solutions and meet project milestones.
The annual base salary for new hires in this position ranges $115,500 to $192,500, with an annual bonus and eligibility for long-term incentives, plus comprehensive benefits.
Matching Summary
Design, execute, and analyze experiments to develop and optimize mRNA purification processes, ensuring scalability and phase-appropriateness for clinical manufacturing.
Salary
Base: $115,500 to $192,500; Bonus/Equity: Annual bonus and long-term incentive program; Benefits: Health care, insurance, retirement, paid holidays, vacation, leave
Skills & Requirements
Must-have
mRNA purification process development
large biomolecules purification
affinity capture
ion exchange
hydrophobic interactions
CMC activities support
Nice-to-have
Quality by Design principles
DOE studies
regulatory guidelines knowledge
nucleic acid analytical technologies
problem-solving skills
collaborative work environment
Key Requirements
Master's or PhD. degree
Five years (Master's) or Three years (PhD.) industry experience
Three or more years purification techniques experience