Analysis of protein structural dynamics and stability
A*STAR BII is seeking a postdoctoral researcher to explore the pH-dependent structural dynamics and receptor-binding behavior of coronavirus spike proteins. The role requires expertise in molecular dynamics simulations and biomolecular modeling to generate insights for future vaccine design and diagnostics
Job Summary
The role involves investigating pH-dependent structural dynamics and receptor-binding behavior of coronavirus spike proteins across multiple variants.
Research will integrate all-atom molecular dynamics simulations to understand how environmental conditions influence viral infectivity and immune evasion.
The position aims to generate mechanistic insights that can inform variant-adapted vaccine design and preparedness for future outbreaks.
Matching Summary
Match Score: 85
A*STAR BII is seeking a postdoctoral researcher to explore the pH-dependent structural dynamics and receptor-binding behavior of coronavirus spike proteins. The role requires expertise in molecular dynamics simulations and biomolecular modeling to generate insights for future vaccine design and diagnostics.
Skills & Requirements
Must-have
PhD in computational chemistry or biophysics
Extensive all-atom molecular dynamics simulations
Analysis of protein structural dynamics and stability
Experience with biomolecular binding interactions
Ability to interpret simulation results biologically
Nice-to-have
Experience with GROMACS, AMBER, or CHARMM packages
Familiarity with enhanced sampling methods
Knowledge of MM/PBSA or binding free energy approaches
Scripting skills in Python or Bash for automation
Collaboration on interdisciplinary experimental projects
Key Requirements
PhD in computational chemistry, biophysics, or biology
Strong expertise in molecular dynamics simulations
Proven publication record in computational biomolecular research