Senior Scientist, Protein Sciences

pfizer.ca

Base: $93,600.00 - $156,000.00; bonus/equity: 12.5...
Protein expression in bacterial, insect, mammalian cells
Protein purification and characterization
Integral membrane protein reconstitution
You will be responsible for expression construct design and purification from bacterial, insect, and mammalian cells, protein quality control, as well as the generation and screening of mutant libraries to generate tools to advance the Pfizer Portfolio of difficult targets

Job Summary

  • You will be responsible for expression construct design and purification from bacterial, insect, and mammalian cells, protein quality control, as well as the generation and screening of mutant libraries to generate tools to advance the Pfizer Portfolio of difficult targets.
  • Your innovation and creativity in developing novel processes and new ideas will be frequently used to drive decision making impact across the portfolio and establish a world-leading Protein Sciences pipeline to serve a world-leading Drug Discovery pipeline.
  • The annual base salary for this position ranges from $93,600.00 to $156,000.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program.

Matching Summary

You will be responsible for expression construct design and purification from bacterial, insect, and mammalian cells, protein quality control, as well as the generation and screening of mutant libraries to generate tools to advance the Pfizer Portfolio of difficult targets.

Salary

Base: $93,600.00 - $156,000.00; Bonus/Equity: 12.5% bonus target, share-based long-term incentive; Benefits: Comprehensive and generous benefits including 401(k), paid time off, medical, dental, vision.

Skills & Requirements

Must-have

  • Protein expression in bacterial, insect, mammalian cells
  • Protein purification and characterization
  • Integral membrane protein reconstitution
  • Akta purification systems
  • Protein chemistry and analytics

Nice-to-have

  • Protein structure analysis
  • Phage/yeast/mRNA library generation
  • Protein design for stabilization
  • Binding approaches for molecules

Key Requirements

  • PhD in Biochemistry, Structural Biology, or related discipline with 1-2 years experience
  • M.S. with 7+ years relevant experience including industry experience
  • Experience with analytical and biophysical methods
  • Experience in expression construct design
  • Demonstrated ability to purify challenging proteins
  • Experience in integral membrane protein reconstitution
  • Permanent work authorization in the United States

Work Rights

Permanent work authorization required

Tailored Resume

Cover Letter