Principal Scientist, Bioinformatics Human Genetics

Genentech

South San Francisco, CA, US
Base: $150,700 to $279,900; bonus/equity: discreti...
Human/statistical genetics expertise
Large-scale genomics data analysis
Ai/ml for genomics
Genentech’s Department of Human Genetics combines large-scale human genetic evidence with rich molecular, cellular, and clinical data to uncover causal disease biology and translate it into actionable targets, biomarkers, and patient stratification strategies

Job Summary

  • Genentech’s Department of Human Genetics combines large-scale human genetic evidence with rich molecular, cellular, and clinical data to uncover causal disease biology and translate it into actionable targets, biomarkers, and patient stratification strategies.
  • The Principal Scientist will lead end-to-end human genetics analyses and advance AI/ML methods to accelerate target discovery, particularly in neuroscience diseases such as Multiple Sclerosis, Parkinson’s disease, and ALS.
  • Relocation benefits are available and the position offers a competitive salary range with discretionary annual bonus and comprehensive benefits.

Matching Summary

Genentech’s Department of Human Genetics combines large-scale human genetic evidence with rich molecular, cellular, and clinical data to uncover causal disease biology and translate it into actionable targets, biomarkers, and patient stratification strategies.

Salary

Base: $150,700 to $279,900; Bonus/Equity: discretionary annual bonus; Benefits: detailed at company link

Skills & Requirements

Must-have

  • human/statistical genetics expertise
  • large-scale genomics data analysis
  • AI/ML for genomics
  • Python and/or R programming
  • reproducible science practices
  • multi-ancestry genetic analyses
  • integration of multimodal genomics

Nice-to-have

  • neuroscience and neurodegeneration focus
  • mentorship and scientific leadership
  • scalable software and workflow development
  • cross-functional collaboration
  • benchmarking and calibration of ML models
  • genetics-informed patient stratification

Key Requirements

  • PhD in related quantitative field with postdoctoral experience
  • proven scientific impact with first/corresponding author publications
  • experience with common- and rare-variant genetic methods
  • strong statistical and programming skills
  • experience with large-scale genomics and compute environments
  • excellent communication and collaboration skills

Work Rights

Not specified

Sponsorship: available

Tailored Resume

Cover Letter