Job Summary

• The Principal Scientist, Disease Modeling & Deep Biology will serve as the scientific authority for building, selecting, and deploying human disease models that enable discovery, mechanistic insight, and therapeutic decision-making across RNA, enzyme, antibody, and emerging modalities.
• This role is centered on disease modeling excellence, not any single technology.
• The successful candidate will bring breadth across biological systems and modalities, combined with deep hands-on expertise (>30% laboratory engagement) and the ability to lead projects and scientists from hypothesis through decision.

Matching Summary

Salary

Base: $148,000 - $208,000 USD; Bonus/Equity: bonus potential and generous early equity; Benefits: Not specified

Skills & Requirements

Key Requirements

• PhD with 5-6+ years or MS with 8+ years industry experience
• Cell Biology, Molecular Biology, Developmental Biology, Immunology background
• Extensive experience designing human disease models
• Demonstrated breadth across therapeutic modalities
• Strong hands-on experimental background
• Experience selecting sequencing, profiling, and molecular characterization technologies
• Familiarity with automation, high-throughput experimentation, or AI/ML-enabled analysis
• Proven ability to lead projects and mentor scientists
• Track record of translating complex biological data
• Willingness to remain actively engaged at the bench

Work Rights