Principal Scientist - Translational Intestinal Immunology (80-100%*)
Novartis UK
Basel, Switzerland
On-site
Mechanistic translational research
Mucosal immunology
Human biosamples
Novartis UK is seeking a Principal Scientist in Translational Intestinal Immunology to lead research in developing therapies for inflammatory bowel diseases. The ideal candidate will have a strong background in mucosal immunology and experience in translational research, with responsibilities including designing experiments and collaborating with clinical teams
Job Summary
Design and execute mechanistic experiments hands-on, to link human disease biology to druggable targets within and beyond the immune system, and to accelerate preclinical compound development, strengthen understanding of drug modes of action, differentiate novel drugs to standard-of care treatment.
Leverage human biosamples (e.g. blood, intestinal biopsies) to generate decision-making data and position candidate molecules for clinical trials (target validation, MoA studies, biomarker strategy).
Champion data-driven target discovery, in collaboration with data scientists, in vivo biology labs and other groups in Novartis Biomedical Research to connect quantitative methods (e.g. ex vivo analyses, transcriptomics) to patient heterogeneity and outcomes.
Matching Summary
Match Score: 85
Novartis UK is seeking a Principal Scientist in Translational Intestinal Immunology to lead research in developing therapies for inflammatory bowel diseases. The ideal candidate will have a strong background in mucosal immunology and experience in translational research, with responsibilities including designing experiments and collaborating with clinical teams.
Skills & Requirements
Must-have
mechanistic translational research
mucosal immunology
human biosamples
preclinical compound development
drug modes of action
multi-parametric flow cytometry
in vitro human models
Nice-to-have
mentoring junior researchers
drug discovery programs
data science literacy
interpreting multi-omic outputs
Key Requirements
PhD or MD qualified
3 years of relevant translational research expertise
Hands-on mastery of immunological/cell biology/molecular biology assays
Proven ability to conduct experiments using in vitro human systems and biosamples
Experienced in collaboration with data scientists
Proven track record of completing projects on schedule