Senior Scientist I, Cell Therapy Discovery

AstraZeneca

Shanghai, China
Not specified (assumed to be hybrid based on industry trends)
Car design and engineering
In vitro functional characterization
Human t-cell isolation and culture
AstraZeneca is seeking a Senior Scientist I for their Cell Therapy Discovery team in Shanghai, China. The ideal candidate will lead CAR construct design and T-cell engineering, applying data-driven approaches and collaborating across functions to advance cell therapy projects

Job Summary

  • You will own key assays and workflows for CAR design, T-cell engineering, and in vitro functional characterization.
  • Apply a rigorous, data-driven approach to experimental design, mechanism-of-action studies, and decision-making.
  • Present results and recommendations to teams; mentor colleagues and foster a productive lab environment.

Matching Summary

Match Score: 85

AstraZeneca is seeking a Senior Scientist I for their Cell Therapy Discovery team in Shanghai, China. The ideal candidate will lead CAR construct design and T-cell engineering, applying data-driven approaches and collaborating across functions to advance cell therapy projects.

Skills & Requirements

Must-have

  • CAR design and engineering
  • in vitro functional characterization
  • Human T-cell isolation and culture
  • Flow cytometry panel design
  • Functional assay development
  • Molecular methods (PCR/qPCR, NGS prep)

Nice-to-have

  • Armored CARs, logic-gated CARs
  • Allogeneic edits
  • Familiarity with AML disease
  • Method transfer and qualification
  • Scale-up evaluations

Key Requirements

  • PhD in immunology, cell biology, or related field
  • MS with 2–3+ years experience
  • Human primary cells and functional co-culture assays
  • Lentiviral transduction MOI optimization
  • Electroporation for gene edits
  • ELN, FlowJo, GraphPad proficiency
  • Basic statistics understanding
  • Biosafety level 2 practices
  • Research GxP awareness

Work Rights

Not specified

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