Staff / Senior Scientist, Bioconjugation Chemistry

Glyphic Biotechnologies

Berkeley, CA, United States
Base: $123,000 - $187,575; bonus/equity: employee ...
On-site
Protein and peptide bioconjugation expertise
Site-specific amino acid sidechain chemistry
Nhs-ester maleimide click chemistry proficiency
Glyphic Biotechnologies is seeking a Staff/Senior Scientist specializing in Bioconjugation Chemistry to join their Chemistry team in Berkeley, CA. The ideal candidate will have extensive experience in protein and peptide bioconjugation and will contribute to the development of innovative approaches for a next-generation proteome sequencing platform

Job Summary

  • The role involves developing first-in-class conjugation chemistry that enables single-molecule protein sequencing at Glyphic Biotechnologies.
  • Candidates will design bioconjugation workflows using NHS-ester, maleimide, and click chemistries while characterizing purity and stability via HPLC and LC-MS/MS.
  • The position offers a collaborative culture with direct impact on product development, high-impact publications, and patents alongside comprehensive benefits.

Matching Summary

Match Score: 85

Glyphic Biotechnologies is seeking a Staff/Senior Scientist specializing in Bioconjugation Chemistry to join their Chemistry team in Berkeley, CA. The ideal candidate will have extensive experience in protein and peptide bioconjugation and will contribute to the development of innovative approaches for a next-generation proteome sequencing platform.

Salary

Base: $123,000 - $187,575; Bonus/Equity: Employee Stock Option Plan included; Benefits: 100% Health coverage, 401(k) match, PTO, parental leave

Skills & Requirements

Must-have

  • Protein and peptide bioconjugation expertise
  • Site-specific amino acid sidechain chemistry
  • NHS-ester maleimide click chemistry proficiency
  • HPLC LC-MS/MS analytical characterization skills
  • Method-development mindset for novel approaches

Nice-to-have

  • Solid-phase peptide synthesis experience
  • Oligonucleotide conjugation techniques
  • Scalable surface chemistry methods
  • DOE-based experimental design familiarity
  • Early-stage biotech company background

Key Requirements

  • PhD or MS in organic chemistry or related field
  • 6+ years industry experience for Senior Scientist level
  • 8+ years industry experience for Staff Scientist level
  • Demonstrated ability to independently troubleshoot conjugation workflows

Work Rights

Not specified

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