Base: $121,250 to $159,500; bonus: annual discreti...
On-site
Phd in biochemistry or molecular biology
Mechanistic biochemistry of nucleic acid-protein complexes
Protein purification and rnp reconstitution
Arc Institute is seeking a Scientist in Nucleic Acid Biochemistry for their Hsu and Konermann Labs in Palo Alto, CA. The role involves leading mechanistic research on Bridge Recombinases to drive innovations in genome editing and therapeutic applications
Job Summary
The role focuses on leading the mechanistic research program to engineer bridge recombinases for megabase-scale genome modifications.
Candidates will design and execute rigorous in vitro assays to dissect substrate recognition, complex assembly, and strand exchange mechanisms.
The position offers long-term funding and industry-like resources within an independent nonprofit research organization at the interface of AI and biology.
Matching Summary
Match Score: 85
Arc Institute is seeking a Scientist in Nucleic Acid Biochemistry for their Hsu and Konermann Labs in Palo Alto, CA. The role involves leading mechanistic research on Bridge Recombinases to drive innovations in genome editing and therapeutic applications.
Salary
Base: $121,250 to $159,500; Bonus: Annual discretionary bonus dependent on performance; Benefits: Not specified
Skills & Requirements
Must-have
PhD in biochemistry or molecular biology
Mechanistic biochemistry of nucleic acid-protein complexes
Protein purification and RNP reconstitution
Quantitative biochemical assay design
In vitro kinetic and binding assays
Nice-to-have
Experience with CRISPR-Cas9 or recombinases
Higher-throughput biochemical assay development
Mammalian cell culture experience
Structural biology conceptual fluency
Collaborative interdisciplinary teamwork
Key Requirements
PhD in biochemistry, molecular biology, biophysics, or related field
0-4 years postdoctoral or equivalent industry experience
Hands-on experience with gene editing enzymes acting on DNA