The role involves leading the discovery of CAR constructs and characterizing engineered cell therapies using human primary cells and functional co-culture assays
Job Summary
The role involves leading the discovery of CAR constructs and characterizing engineered cell therapies using human primary cells and functional co-culture assays.
Candidates must apply a rigorous, data-driven approach to experimental design while documenting work to high standards and utilizing advanced analytics.
The position requires driving alignment across multiple teams including Pharmacology & Toxicology, CMC, and clinical groups while mentoring junior colleagues.
Matching Summary
The role involves leading the discovery of CAR constructs and characterizing engineered cell therapies using human primary cells and functional co-culture assays.
Skills & Requirements
Must-have
Fresh PhD in immunology or cell biology
Human T-cell isolation and culture
Lentiviral transduction MOI optimization
Flow cytometry panel design and analysis
Functional assays for target killing
Molecular methods PCR qPCR amplicon NGS
Biosafety level 2 practices compliance
Nice-to-have
Experience with armored CARs or allogeneic edits
Advancing CAR-T candidates through lead optimization
Scale-up evaluations and CQA familiarity
Strong organizational skills under pressure
Enthusiasm for personalized healthcare aims
Key Requirements
Fresh PhD in immunology, cell biology, or related field
MS with 5+ years demonstrated impact in cell therapy discovery
Proficiency with ELN, FlowJo, and GraphPad software
Knowledge of biosafety level 2 practices and IACUC ethics
Understanding of assay acceptance criteria and basic statistics