Leverage modeling skills and knowledge of computational chemistry to support the design and prioritization of new small molecules aimed to treat neurological and rare diseases
Job Summary
Leverage modeling skills and knowledge of computational chemistry to support the design and prioritization of new small molecules aimed to treat neurological and rare diseases.
Apply advanced structure based methods, including binding site analysis, pose prediction, and structure guided SAR development, to influence and prioritize compound design.
Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being.
Matching Summary
Leverage modeling skills and knowledge of computational chemistry to support the design and prioritization of new small molecules aimed to treat neurological and rare diseases.
Salary
Base: $141,000.00-$188,000.00; Bonus/Equity: Short term and long-term incentives, cash bonus and equity incentive opportunities; Benefits: Medical, Dental, Vision, Life insurances, Fitness & Wellness programs, Disability insurance, Paid time off, Holidays, Paid Maternity and Parental Leave, 401(k) with match, ESPP, Tuition reimbursement
Skills & Requirements
Must-have
structure based drug design
Free Energy Perturbation (FEP) calculations
molecular dynamics simulations
docking and ligand based methods
machine learning and QSAR modeling
multidisciplinary team collaboration
Nice-to-have
creative and highly motivated scientist
stay current with chemical literature
independent problem solving
support medicinal chemistry optimization
build automated workflows and pipelines
Key Requirements
Ph.D. in computational chemistry, cheminformatics, or related computational science discipline
5+ years pharma or biotech experience
Hands-on experience with FEP workflows
Proficiency in molecular dynamics with enhanced sampling
Demonstrated impact using docking, ligand based modeling, virtual screening, QM methods, and machine learning approaches
Track record of publications and/or scientific presentations