Principal Scientist / Associate Director, Biochemistry

Treeline Biosciences

Watertown, Massachusetts, United States
Base: $174,500 to $196,700; bonus/equity: not spec...
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Phd in enzymology or biochemistry
7+ years biotech/pharma experience
Small molecule drug discovery expertise
** Treeline Biosciences is seeking a Principal Scientist / Associate Director in Biochemistry to drive drug discovery efforts in their Watertown, Massachusetts location. The ideal candidate should possess significant experience in biochemistry, enzymology, and drug development, with strong leadership capabilities for managing a team and cross-functional collaboration. **

Job Summary

  • Treeline Biosciences is seeking a motivated Biochemist to join their drug discovery team focused on developing therapeutics for previously undrugged targets.
  • The successful candidate will design and execute experiments including mechanistic exploration, HTS screens, and hit finding activities while managing a team at the Associate Director level.
  • This role requires integrating mechanistic data with structural biology and medicinal chemistry to prioritize follow-up chemistry and propose optimization strategies.

Matching Summary

Match Score: 75

** Treeline Biosciences is seeking a Principal Scientist / Associate Director in Biochemistry to drive drug discovery efforts in their Watertown, Massachusetts location. The ideal candidate should possess significant experience in biochemistry, enzymology, and drug development, with strong leadership capabilities for managing a team and cross-functional collaboration. **

Salary

Base: $174,500 to $196,700; Bonus/Equity: Not specified; Benefits: Not specified

Skills & Requirements

Must-have

  • PhD in Enzymology or Biochemistry
  • 7+ years biotech/pharma experience
  • Small molecule drug discovery expertise
  • Mechanistic enzymology and kinetics
  • Steady-state and pre-steady-state assays
  • FP, TR-FRET, and bead-based assays
  • Team management for Associate Director level

Nice-to-have

  • Strong quantitative modeling skills
  • Experience with difficult to drug targets
  • Cross-functional collaboration abilities
  • Creative approach to scientific challenges
  • Mentorship and team development focus

Key Requirements

  • PhD in Enzymology, Biochemistry, Biophysics or related discipline
  • 7+ years industry experience (MS with 12+ years)
  • 3+ years management experience for Associate Director level
  • Track record in small molecule inhibitor characterization
  • Proven experience with challenging protein targets

Work Rights

Not specified

Tailored Resume

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