Postdoctoral Fellow – Ai Enabled Gpcr Structural Biology (cryo-em)

Pfizer

Connecticut, United States
Base: $64,600.00 - $107,600.00; bonus/equity: 7.5%...
On-site
Gpcr structural biology
Cryo-electron microscopy (cryo-em)
Ai-enabled experimental strategies
Pfizer is hiring a highly motivated Postdoctoral Fellow specializing in structural biology, particularly in G protein-coupled receptors (GPCRs) and cryo-electron microscopy (cryo-EM). The role focuses on advancing structure-based drug discovery through experimental strategies and collaboration with AI/ML scientists

Job Summary

  • Advance next-generation structure-based drug discovery by integrating pharmacology, cryo-EM, and AI-enabled experimental strategies to interrogate dynamic GPCR functional states.
  • Design and execute experimental strategies to characterize GPCR functional states that are dynamic, transient, or conformationally heterogeneous.
  • Collaborate with multidisciplinary teams across structural biology, pharmacology, computational sciences, and medicinal chemistry, including close interaction with an AI/ML-focused postdoctoral collaborator.

Matching Summary

Match Score: 85

Pfizer is hiring a highly motivated Postdoctoral Fellow specializing in structural biology, particularly in G protein-coupled receptors (GPCRs) and cryo-electron microscopy (cryo-EM). The role focuses on advancing structure-based drug discovery through experimental strategies and collaboration with AI/ML scientists.

Salary

Base: $64,600.00 - $107,600.00; Bonus/Equity: 7.5% bonus target; Benefits: Comprehensive and generous benefits program

Skills & Requirements

Must-have

  • GPCR structural biology
  • cryo-electron microscopy (cryo-EM)
  • AI-enabled experimental strategies
  • membrane protein structural biology
  • design and execute experimental strategies
  • biochemical and cell-based pharmacology assays

Nice-to-have

  • data-driven model-refinement framework
  • scientific curiosity
  • shape scientific direction

Key Requirements

  • Ph.D. in Structural Biology, Biochemistry, Pharmacology, Biophysics, Chemical Biology, or related discipline
  • Hands-on experience with cryo-EM workflows
  • Background in membrane-protein or GPCR construct design
  • Experience curating, analyzing, and interpreting structural and functional datasets
  • Proven ability to work effectively in a collaborative, multidisciplinary research environment
  • Strong written and verbal communication skills

Work Rights

Permanent work authorization in the United States

Tailored Resume

Cover Letter