Novartis UK is seeking a Principal Scientist to lead research efforts in autosomal dominant polycystic kidney disease (ADPKD) in Cambridge, MA. The ideal candidate will have extensive experience in kidney disease research and drug discovery, with a strong focus on translating genetic insights into therapeutic strategies
Job Summary
The Principal Scientist, ADPKD Biology Lead is a senior, lab-embedded scientific leader responsible for shaping and executing ADPKD discovery biology strategy across a portfolio of preclinical programs.
Lead a portfolio of renal discovery programs from target hypothesis through preclinical proof-of-concept (PoC) and transition toward clinical candidate selection.
The salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and $126,000 and $234,000 per year for Principal Scientist II.
Matching Summary
Match Score: 85
Novartis UK is seeking a Principal Scientist to lead research efforts in autosomal dominant polycystic kidney disease (ADPKD) in Cambridge, MA. The ideal candidate will have extensive experience in kidney disease research and drug discovery, with a strong focus on translating genetic insights into therapeutic strategies.
Salary
Base: $108,500.00 - $234,000.00; Bonus/Equity: Performance-based cash incentive and annual equity awards; Benefits: Comprehensive benefits package including health, life, disability, 401(k) with company contribution and match, generous time off
Skills & Requirements
Must-have
ADPKD discovery biology strategy
target triage and validation
human-relevant model systems
decision-grade biology packages
renal cyst pathophysiology
Nice-to-have
external scientific and competitive landscape
emerging targets and modalities
partnership opportunities
Key Requirements
PhD in relevant scientific discipline
8-10+ years of experience in kidney disease research
Meaningful drug discovery experience
Deep expertise in ADPKD biology
Experience across multiple stages of drug discovery
Strong hands-on understanding of state-of-the-art in vitro methods