Associate Principal Scientist, Mammalian Cell Line Engineering And Expression Optimization For Adcs And Bispecifics, With Focus On Non Natural Amino Acid Expression Systems

Astrazeneca

Base: $142,377.60 to $213,566.40; bonus/equity: el...
Not specified
Mammalian cell line engineering
Expression optimization
Non-natural amino acid expression
AstraZeneca is seeking an Associate Principal Scientist to lead mammalian cell line engineering and expression optimization for antibody-drug conjugates (ADCs) and bispecific antibodies, with a focus on non-natural amino acid expression systems. The position requires significant expertise in molecular biology and protein expression within a collaborative oncology research environment

Job Summary

  • You will architect and integrate modern vector designs, site‑specific genomic integration, and process‑aware molecular engineering in CHO and HEK platforms, partnering closely with protein engineering, conjugation chemistry, analytics, and translational teams to deliver differentiated biologics for oncology.
  • Own the evolution of our nnAA expression system, driving enhancements in vector architecture, genomic context, secretory pathway tuning, and process parameters to improve titer, consistency, and cell‑line stability; champion adoption across oncology programs.
  • AstraZeneca offers an environment where your expertise has tangible impact.

Matching Summary

Match Score: 85

AstraZeneca is seeking an Associate Principal Scientist to lead mammalian cell line engineering and expression optimization for antibody-drug conjugates (ADCs) and bispecific antibodies, with a focus on non-natural amino acid expression systems. The position requires significant expertise in molecular biology and protein expression within a collaborative oncology research environment.

Salary

Base: $142,377.60 to $213,566.40; Bonus/Equity: eligibility for various incentives, short-term incentive bonuses, equity-based awards; Benefits: qualified retirement programs, paid time off, health, dental, and vision coverage

Skills & Requirements

Must-have

  • mammalian cell line engineering
  • expression optimization
  • non-natural amino acid expression
  • CHO and HEK platforms
  • vector and construct design
  • site-specific genomic integration

Nice-to-have

  • cross-functional influence
  • automation and scale-out
  • data integrity and decision packages
  • people leadership and mentoring
  • collaboration with protein engineering

Key Requirements

  • PhD with 3+ years experience
  • Master’s with 6+ years experience
  • Bachelor’s with 8+ years experience
  • Proven expertise in mammalian cell line engineering
  • Hands-on experience in CHO and/or HEK systems
  • Track record of leading projects and mentoring scientists

Work Rights

Not specified

Tailored Resume

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