Principal Scientist, Chemical Biology - Discovery Chemistry
Johnson & Johnson UK
Beerse, Belgium
Onsite
Organic synthesis
Chemical biology expertise
Designing and synthesizing chemical biology tools
Drive and direct chemical biology functions for drug discovery projects, working in concert with partners in medicinal chemistry, chemoproteomics, disease area biology, and other key functions
Job Summary
Drive and direct chemical biology functions for drug discovery projects, working in concert with partners in medicinal chemistry, chemoproteomics, disease area biology, and other key functions.
Independently design and synthesize chemical biology tools—including photoaffinity and photocatalytic proximity labeling probes—toward various applications, as well as supervise and direct synthetic chemistry activities at contract research organizations (CROs).
Forge a robust relationship with Discovery Technologies & Molecular Pharmacology (DTMP) Chemoproteomics team to design, propose, and implement chem bio strategies and workstreams to best align with Therapeutics Discovery overall goals.
Matching Summary
Drive and direct chemical biology functions for drug discovery projects, working in concert with partners in medicinal chemistry, chemoproteomics, disease area biology, and other key functions.
Skills & Requirements
Must-have
organic synthesis
chemical biology expertise
designing and synthesizing chemical biology tools
photoaffinity and photocatalytic proximity labeling probes
chemoproteomics methods
target identification from phenotypic screens
target engagement in cells or lysate
covalent inhibitor selectivity profiling
binding site identification
small-molecule mechanism of action elucidation
Nice-to-have
biopharmaceutical industry experience
targeted protein degradation strategies
Key Requirements
PhD in Organic Chemistry, Medicinal Chemistry, or Chemical Biology
5+ years of post-PhD experience in Chemical Biology
Structure-Activity Relationship (SAR)-driven design and synthesis of small molecules
chemical biology and chemoproteomics methods
scientific contributions including peer-reviewed first-author publications