Principal Scientist, Computational Chemistry

Biogen

Cambridge, MA, United States
Base: $141,000.00-$188,000.00; bonus/equity: cash ...
Structure based drug design
Free energy perturbation (fep) calculations
Molecular dynamics simulations
Leverage modeling skills and knowledge of computational chemistry to support the design and prioritization of new small molecules aimed to treat neurological and rare diseases

Job Summary

  • Leverage modeling skills and knowledge of computational chemistry to support the design and prioritization of new small molecules aimed to treat neurological and rare diseases.
  • Apply advanced structure based methods, including binding site analysis, pose prediction, and structure guided SAR development, to influence and prioritize compound design.
  • Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being.

Matching Summary

Leverage modeling skills and knowledge of computational chemistry to support the design and prioritization of new small molecules aimed to treat neurological and rare diseases.

Salary

Base: $141,000.00-$188,000.00; Bonus/Equity: Cash bonus and equity incentive opportunities; Benefits: Medical, Dental, Vision, & Life insurances, Fitness & Wellness programs, Disability insurance, paid time off, holidays, paid leave, 401(k) match, ESPP, tuition reimbursement

Skills & Requirements

Must-have

  • structure based drug design
  • Free Energy Perturbation (FEP) calculations
  • molecular dynamics simulations
  • ligand based methods
  • machine learning
  • QSAR modeling

Nice-to-have

  • creative and highly motivated scientist
  • stay current with chemical literature
  • thinking independently
  • multidisciplinary team collaboration
  • building predictive models

Key Requirements

  • Ph.D. in computational chemistry, cheminformatics, or related computational science discipline
  • 5+ years of pharma or biotech experience
  • Hands-on experience with FEP workflows
  • Proficiency in molecular dynamics
  • Demonstrated impact using docking, ligand based modeling, virtual screening, QM methods, and machine learning approaches
  • Track record of publications, and/or scientific presentations
  • Excellent oral and written communication skills

Work Rights

Not specified

Tailored Resume

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