Senior Scientist Ii/associate Principal Scientist, Pharmacology

Trzdev36

Not specified (assumed to be hybrid based on typical industry practices).
In vivo pharmacology
Immune monitoring
Humanized mouse platforms
The Senior Scientist II/Associate Principal Scientist in Pharmacology at Trzdev36 will lead in vivo pharmacology and immune monitoring programs, focusing primarily on CAR-T cell therapy, immuno-oncology, and immunology. This role requires substantial expertise in humanized mouse models and CAR-T biology, with responsibilities ranging from study design to data analysis and cross-functional collaboration

Job Summary

  • You will lead in vivo pharmacology and immune monitoring to enable data-driven progression of programs from discovery toward translation, with priority focus on (1) cell therapy (CAR-T), followed by (2) immuno-oncology and (3) immunology.
  • You will own key humanized mouse platforms and associated ex vivo and in vivo CAR-T characterization workflows, delivering rigorous, decision-enabling datasets that inform candidate selection, dose/regimen strategy, mechanism-of-action understanding, and translational biomarker hypotheses.
  • AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.

Matching Summary

Match Score: 85

The Senior Scientist II/Associate Principal Scientist in Pharmacology at Trzdev36 will lead in vivo pharmacology and immune monitoring programs, focusing primarily on CAR-T cell therapy, immuno-oncology, and immunology. This role requires substantial expertise in humanized mouse models and CAR-T biology, with responsibilities ranging from study design to data analysis and cross-functional collaboration.

Skills & Requirements

Must-have

  • in vivo pharmacology
  • immune monitoring
  • humanized mouse platforms
  • CAR-T characterization
  • flow cytometry
  • study leadership
  • ELN and analysis tools

Nice-to-have

  • translational biomarker strategy
  • immuno-oncology combination strategies
  • tumor microenvironment readouts
  • assay method transfer

Key Requirements

  • PhD or equivalent
  • Small animal in vivo expertise
  • Humanized mouse experience
  • CAR-T biology literacy
  • Flow cytometry competence
  • Study leadership and vendor management
  • Strong English communication

Work Rights

Not specified

Tailored Resume

Cover Letter