Principal Scientist, Upstream Process, Process Development
Legend Biotech
Somerset, New Jersey, United States
On-site
Lentivirus upstream process development
Mammalian cell culture hek293
Transient transfection optimization
The Principal Scientist will lead the design and optimization of upstream production processes for lentiviral vectors to support advanced cell therapy programs
Job Summary
The Principal Scientist will lead the design and optimization of upstream production processes for lentiviral vectors to support advanced cell therapy programs.
This role requires deep expertise in mammalian cell culture, specifically HEK293 and HEK293T, along with transient transfection and bioreactor operations.
The successful candidate will guide a team of scientists while ensuring seamless technology transfer from bench-scale to GMP manufacturing environments.
Matching Summary
The Principal Scientist will lead the design and optimization of upstream production processes for lentiviral vectors to support advanced cell therapy programs.
Skills & Requirements
Must-have
Lentivirus Upstream Process Development
Mammalian Cell Culture HEK293
Transient Transfection Optimization
Bioreactor Scale-Up Models
GMP Manufacturing Compliance
Nice-to-have
Team Leadership Experience
Regulatory Submission Support
Technology Transfer Skills
Continuous Improvement Culture
Key Requirements
PhD or MS in Chemical/Biomedical Engineering or related field
8+ years experience (PhD) or 10+ years (MS) in process development
Hands-on experience with viral vector production
Proven expertise in bioreactor scale-up and scale-down models