Senior Research Scientist, Chemical Biology & Proteomics

AstraZeneca

Waltham, MA, USA
Base: $116,284.00 - $174,426.00 usd annual; bonus/...
Phd with 2+ years post-doctoral or industrial experience
Hands-on quantitative mass spectrometry method development
Experience with ip-ms or chemical probe-based enrichment workflows
The role involves developing chemical tools and proteomics technologies to provide mechanistic insights for drug discovery projects across therapeutic areas

Job Summary

  • The role involves developing chemical tools and proteomics technologies to provide mechanistic insights for drug discovery projects across therapeutic areas.
  • Candidates will be responsible for designing and executing experimental plans to understand target engagement and selectivity profiles of therapeutic agents.
  • AstraZeneca offers an inclusive culture that champions diversity, collaboration, and lifelong learning while empowering employees to push the boundaries of science.

Matching Summary

The role involves developing chemical tools and proteomics technologies to provide mechanistic insights for drug discovery projects across therapeutic areas.

Salary

Base: $116,284.00 - $174,426.00 USD Annual; Bonus/Equity: Short-term incentive bonus and equity-based long-term incentive program eligibility; Benefits: Retirement contribution and commission payment eligibility mentioned

Skills & Requirements

Must-have

  • PhD with 2+ years post-doctoral or industrial experience
  • Hands-on quantitative mass spectrometry method development
  • Experience with IP-MS or chemical probe-based enrichment workflows
  • Expertise in TMT, SILAC, label-free, and DIA approaches
  • Skilled in investigating compound effects under biochemical settings

Nice-to-have

  • Experience with robotic automation and liquid handling systems
  • Familiarity with targeted proteomics techniques
  • Positive result-oriented and problem-solving attitude
  • Significant external reputation through publications
  • Experience using Thermo Q-Exactive or Orbitrap instruments

Key Requirements

  • PhD degree required
  • Minimum 2 years post-doctoral or industrial experience
  • Proven expertise in mass spectrometry-based covalent screening
  • Strong data analysis and communication skills
  • Publication record in high-impact journals

Work Rights

Not specified

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