Associate Principal Scientist, Mammalian Cell Line Engineering And Expression Optimization For Adcs And Bispecifics, With Focus On Non Natural Amino Acid Expression Systems

medizinstellenmarkt.de

Base: $142,377.60 - $213,566.40; bonus/equity: eli...
Not specified (potentially hybrid or onsite based on industry norms).
Mammalian cell line engineering
Expression optimization
Adcs and bispecific antibodies
The Associate Principal Scientist position at AstraZeneca focuses on advancing mammalian cell line engineering and expression optimization, particularly for antibody-drug conjugates (ADCs) and bispecific antibodies. The role requires strong scientific leadership and collaboration with cross-functional teams to enhance productivity and product quality through innovative expression systems

Job Summary

  • You will provide scientific and strategic leadership for mammalian cell line engineering and expression optimization to accelerate discovery of antibody–drug conjugates (ADCs) and bispecific antibodies.
  • A central focus is advancing our in‑house non‑natural amino acid (nnAA) expression system, driving step‑change improvements in productivity, stability, and product quality through host, vector, and process innovations.
  • The annual base pay (or hourly rate of compensation) for this position ranges from $142,377.60 to $213,566.40.

Matching Summary

Match Score: 85

The Associate Principal Scientist position at AstraZeneca focuses on advancing mammalian cell line engineering and expression optimization, particularly for antibody-drug conjugates (ADCs) and bispecific antibodies. The role requires strong scientific leadership and collaboration with cross-functional teams to enhance productivity and product quality through innovative expression systems.

Salary

Base: $142,377.60 - $213,566.40; Bonus/Equity: eligibility for short-term incentive bonuses, equity-based awards; Benefits: qualified retirement programs, paid time off, health, dental, and vision coverage

Skills & Requirements

Must-have

  • Mammalian cell line engineering
  • Expression optimization
  • ADCs and bispecific antibodies
  • Non-natural amino acid expression
  • CHO and HEK platforms
  • Vector and construct design
  • Site-specific genomic integration

Nice-to-have

  • Cross-functional collaboration
  • Automation and high-throughput screening
  • Data integrity and decision packages
  • People leadership and mentoring
  • Fast-paced oncology research environment

Key Requirements

  • PhD with 3+ years or Master’s with 6+ years or Bachelor’s with 8+ years of industry experience
  • Proven expertise in mammalian cell line engineering
  • Hands-on experience in CHO and/or HEK systems
  • Track record of leading projects and mentoring scientists

Work Rights

Not specified

Tailored Resume

Cover Letter