Front Line Manufacturing Manager - Downstream Bulk Drug Substance - Days

Amgen Inc

North Carolina, US
Base: $106,148.00 - $143,612.00 usd annually; bonu...
Hybrid (initially remote during startup phase, transitioning to in-person for 12-hour shifts)
Downstream purification operations management
Cgmp compliant manufacturing execution
Facility startup and commissioning support
Amgen Inc is seeking a Front Line Manufacturing Manager for their Downstream Bulk Drug Substance operations in North Carolina. This leadership position will support the startup and operational readiness of a new manufacturing facility and requires strong experience in manufacturing and operations, particularly in biologics and cGMP environments

Job Summary

  • This role provides frontline leadership to support the facility expansion program and startup of Amgen's newest FleX Batch facility.
  • The position requires managing downstream purification operations including column chromatography, TFF, and viral filtration while ensuring cGMP compliance.
  • Amgen offers a comprehensive benefits package including retirement plans, health coverage, stock-based incentives, and flexible work models.

Matching Summary

Match Score: 85

Amgen Inc is seeking a Front Line Manufacturing Manager for their Downstream Bulk Drug Substance operations in North Carolina. This leadership position will support the startup and operational readiness of a new manufacturing facility and requires strong experience in manufacturing and operations, particularly in biologics and cGMP environments.

Salary

Base: $106,148.00 - $143,612.00 USD annually; Bonus: Discretionary annual bonus program; Benefits: Comprehensive health, dental, vision, retirement plan, and stock incentives

Skills & Requirements

Must-have

  • Downstream purification operations management
  • cGMP compliant manufacturing execution
  • Facility startup and commissioning support
  • 12-hour shift work availability
  • Team leadership and performance coaching

Nice-to-have

  • Experience with disposable technologies
  • Sustainability innovation implementation
  • Technology transfer and ramp-up skills
  • Continuous improvement mindset
  • Cross-functional collaboration expertise

Key Requirements

  • Doctorate OR Master's + 3 years experience OR Bachelor's + 5 years in Manufacturing/Operations
  • Previous managerial experience directly managing people or leading teams
  • Bachelor's degree in Life Sciences or Engineering (Preferred)
  • 5+ years cGMP manufacturing experience (Preferred)

Work Rights

Not specified

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