Post Doctoral Fellow-msh-12908-019

Mount Sinai Health System

New York, NY, US
Hippo pathway signaling
Podocyte injury
Glomerular disease
Our lab has identified Hippo pathway upstream regulator KIBRA (Kidney BRAin) protein as a novel mediator of podocyte injury via inhibition of downstream pro-survival transcriptional co-activator YAP

Job Summary

  • Our lab has identified Hippo pathway upstream regulator KIBRA (Kidney BRAin) protein as a novel mediator of podocyte injury via inhibition of downstream pro-survival transcriptional co-activator YAP.
  • We aim to test this hypothesis and the potential therapeutic role of small molecule Hippo mediators using complementary models including immortalized podocytes, hIPSC-derived podocytes and kidney organoids, diabetic rodent models, and banked human kidney tissue/biosamples.
  • The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence.

Matching Summary

Our lab has identified Hippo pathway upstream regulator KIBRA (Kidney BRAin) protein as a novel mediator of podocyte injury via inhibition of downstream pro-survival transcriptional co-activator YAP.

Skills & Requirements

Must-have

  • Hippo pathway signaling
  • podocyte injury
  • glomerular disease
  • Aseptic cell culture
  • Western blotting
  • PCR/qPCR
  • Immunofluorescence/immunohistochemistry
  • Confocal and TIRF microscopy
  • Rodent animal handling

Nice-to-have

  • therapeutic role of small molecule mediators
  • diabetic milieu
  • actin cytoskeleton
  • focal adhesion complexes

Key Requirements

  • Bachelors and Masters or Doctoral Degree
  • at least 2 years in lab environment

Work Rights

Not specified

Tailored Resume

Cover Letter