Oligo Discovery Chemistry Principal Scientist

GlaxoSmithKline

Cambridge, MA, US
Base: $121,275 to $202,125 annually; bonus/equity:...
Full-time onsite
Phd in chemistry or chemical biology
3+ years industry experience in nucleoside synthesis
Expertise in spos of asos, sirna, sso, and rna editors
GlaxoSmithKline (GSK) is seeking a Principal Scientist in Oligo Discovery Chemistry to establish pre-clinical capabilities in their oligonucleotide synthesis lab. The ideal candidate will have extensive experience in oligonucleotide synthesis and modern synthetic chemistry methods, contributing to the development of innovative therapeutic solutions

Job Summary

  • The role involves establishing pre-clinical capabilities within GSK's new oligo synthesis lab to accelerate significant assets meeting patient needs.
  • Candidates will lead key activities including developing discovery mid-scale workflows and serving as the subject matter expert for the team.
  • The position offers a competitive annual base salary ranging from $121,275 to $202,125 along with bonus eligibility and comprehensive benefits.

Matching Summary

Match Score: 85

GlaxoSmithKline (GSK) is seeking a Principal Scientist in Oligo Discovery Chemistry to establish pre-clinical capabilities in their oligonucleotide synthesis lab. The ideal candidate will have extensive experience in oligonucleotide synthesis and modern synthetic chemistry methods, contributing to the development of innovative therapeutic solutions.

Salary

Base: $121,275 to $202,125 annually; Bonus/Equity: Annual bonus and share based long term incentive program eligible; Benefits: Health care, retirement, paid holidays, vacation, and parental leave

Skills & Requirements

Must-have

  • PhD in chemistry or chemical biology
  • 3+ years industry experience in nucleoside synthesis
  • Expertise in SPOS of ASOs, siRNA, SSO, and RNA editors
  • Hands-on experience with ÄKTA Oligosynt synthesizers
  • Proficiency in LC/HRMS, UPHLC, and LC/MS analytics
  • Experience developing standard operating procedures (SOPs)

Nice-to-have

  • Experience with oligonucleotide conjugation chemistries
  • Strong scientific mentorship and project leadership skills
  • Excellent written and verbal communication abilities
  • Demonstrated ability to balance multiple priorities
  • Commitment to team-based culture and collaboration

Key Requirements

  • PhD degree required
  • Minimum 3 years of relevant industry experience
  • 2+ years in modern synthetic chemistry methods
  • Familiarity with Cytiva purification systems
  • Prior experience with scientific mentorship

Work Rights

Not specified

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