Senior Research Scientist, Chemical Biology & Proteomics

AstraZeneca

Waltham, MA, United States
Base: $116,284.00 - $174,426.00 usd annual; bonus/...
On-site
Chemical tools and proteomics technologies
Mass spectrometry-based methods
Target engagement and selectivity profiles
AstraZeneca is looking for a Senior Research Scientist in Chemical Biology & Proteomics to join their team in Waltham, MA. The ideal candidate will have extensive experience in mass spectrometry and drug discovery, contributing to the development of pre-clinical pharmacology data for therapeutic agents

Job Summary

  • Develop and employ chemical tools and proteomics technologies to provide impactful mechanistic insights for drug discovery projects across therapeutic areas.
  • Design and execute experimental plans to understand target engagement and selectivity profiles of therapeutic agents, understand drug-induced proteome dynamics and investigate post-translational modifications (PTM).
  • Maintain and troubleshoot LC-MS systems.

Matching Summary

Match Score: 85

AstraZeneca is looking for a Senior Research Scientist in Chemical Biology & Proteomics to join their team in Waltham, MA. The ideal candidate will have extensive experience in mass spectrometry and drug discovery, contributing to the development of pre-clinical pharmacology data for therapeutic agents.

Salary

Base: $116,284.00 - $174,426.00 USD Annual; Bonus/Equity: short-term incentive bonus opportunity, equity-based long-term incentive program; Benefits: retirement contribution, commission payment eligibility

Skills & Requirements

Must-have

  • chemical tools and proteomics technologies
  • mass spectrometry-based methods
  • target engagement and selectivity profiles
  • drug-induced proteome dynamics
  • post-translational modifications (PTM)
  • LC-MS system maintenance

Nice-to-have

  • pre-clinical drug discovery experience
  • liquid handling systems and robotic automation
  • targeted proteomics experience

Key Requirements

  • PhD with 2+ years of post-doctoral/industrial experience
  • Knowledge and hands-on experience with quantitative mass spectrometry
  • Experience with mass spectrometry-based covalent screening
  • Expertise in IP-MS or chemical probe-based enrichment MS workflows
  • Skilled in investigating compound effects with quantitative mass spectrometry
  • Experience in determining protein abundance and turnover
  • Expertise in data analysis and clear communication of interpretation
  • Significant external reputation through professional recognition, presentations and publications

Work Rights

Not specified

Tailored Resume

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