Ai-enabled Ipsc Disease Modeling & Functional Genomics

Sanofi Genzyme

Cambridge, MA, US
Base: $75,000.00 - $108,333.33; bonus/equity: not ...
Hybrid
Human ipsc culture and banking
Crispr/cas9 genome editing in ipscs
Differentiation into cns cell types
This role focuses on defining molecular mechanisms of neurodegenerative diseases like Alzheimer's and ALS using high-resolution human models

Job Summary

  • This role focuses on defining molecular mechanisms of neurodegenerative diseases like Alzheimer's and ALS using high-resolution human models.
  • The successful candidate will design, generate, and characterize isogenic iPSC lines and develop robust phenotypic assays for hit-finding.
  • Sanofi offers a supportive team environment with comprehensive benefits including at least 14 weeks of gender-neutral parental leave.

Matching Summary

This role focuses on defining molecular mechanisms of neurodegenerative diseases like Alzheimer's and ALS using high-resolution human models.

Salary

Base: $75,000.00 - $108,333.33; Bonus/Equity: Not specified; Benefits: Comprehensive health, wellness, and parental leave included

Skills & Requirements

Must-have

  • Human iPSC culture and banking
  • CRISPR/Cas9 genome editing in iPSCs
  • Differentiation into CNS cell types
  • High-content imaging assay development
  • TDP-43 biology and proteinopathies

Nice-to-have

  • Co-culture and tri-culture system experience
  • AI/machine learning image analysis
  • Pooled or arrayed CRISPR screen execution
  • Neurodegenerative disease research background
  • R or Python programming for data QC

Key Requirements

  • BS degree with 4+ years relevant lab experience OR MS with 2+ years
  • Hands-on proficiency in human iPSC differentiation into CNS cell types
  • Experience developing plate-based and high-content imaging assays

Work Rights

Not specified

Tailored Resume

Cover Letter