Legend Biotech is seeking a Principal Scientist to lead early process development for a manufacturable lentiviral vector platform supporting in-vivo CAR-T programs
Job Summary
Legend Biotech is seeking a Principal Scientist to lead early process development for a manufacturable lentiviral vector platform supporting in-vivo CAR-T programs.
The role requires establishing seed train strategies, optimizing media and feeding strategies, and defining critical process parameters for scalable bioreactor manufacturing.
This senior individual contributor will serve as a scientific cornerstone bridging construct-level design decisions with upstream process outcomes to ensure end-to-end process coherence.
Matching Summary
Legend Biotech is seeking a Principal Scientist to lead early process development for a manufacturable lentiviral vector platform supporting in-vivo CAR-T programs.
Skills & Requirements
Must-have
Lentiviral vector (LVV) process development
Upstream bioprocess engineering
Molecular biology expertise
Transient transfection systems
Stable producer cell line platforms
Design of Experiments (DoE)
Bioreactor scale-up to 40-L
Nice-to-have
Cross-functional collaboration skills
Mechanistic understanding of processes
Regulatory filing experience
Technical leadership capabilities
Data-driven decision making
Key Requirements
PhD or equivalent advanced degree in relevant field
Extensive experience in lentiviral vector production
Proven track record in upstream process development