Senior Scientist Ii/associate Principal Scientist, Pharmacology

AstraZeneca

Shanghai, China
Not specified
Humanized mouse car-t in vivo strategy
In vitro car-t functional characterization
Small animal oncology study design
AstraZeneca is seeking a Senior Scientist II/Associate Principal Scientist in Pharmacology to lead in vivo pharmacology and immune monitoring, particularly focusing on CAR-T therapies and immuno-oncology. The ideal candidate will possess extensive experience in humanized mouse models, CAR-T biology, and study leadership

Job Summary

  • You will lead in vivo pharmacology and immune monitoring to enable data-driven progression of programs from discovery toward translation, with priority focus on cell therapy (CAR-T), immuno-oncology, and immunology.
  • You will own key humanized mouse platforms and associated ex vivo and in vivo CAR-T characterization workflows, delivering rigorous, decision-enabling datasets that inform candidate selection, dose/regimen strategy, and mechanism-of-action understanding.
  • You will drive alignment with Cell Therapy discovery/in vitro teams, Translational Science, Bioanalytics, Pathology, CMC, and Clinical colleagues, presenting results, risks, and recommendations in cross-functional forums.

Matching Summary

Match Score: 85

AstraZeneca is seeking a Senior Scientist II/Associate Principal Scientist in Pharmacology to lead in vivo pharmacology and immune monitoring, particularly focusing on CAR-T therapies and immuno-oncology. The ideal candidate will possess extensive experience in humanized mouse models, CAR-T biology, and study leadership.

Skills & Requirements

Must-have

  • Humanized mouse CAR-T in vivo strategy
  • In vitro CAR-T functional characterization
  • Small animal oncology study design
  • End-to-end study delivery
  • Flow cytometry-based immunophenotyping
  • Rigorous experimental design principles

Nice-to-have

  • Experience establishing CAR-T pipelines
  • Immune profiling across tissues
  • Immuno-oncology combination strategies

Key Requirements

  • PhD or MD with substantial research experience
  • Demonstrated small animal in vivo expertise
  • Practical humanized mouse experience
  • Strong CAR-T biology and evaluation literacy
  • Flow cytometry competence
  • Proven study leadership and vendor management
  • Proficiency with ELN and analysis/visualization tools
  • Strong animal ethics and welfare mindset
  • Strong English communication skills

Work Rights

Not specified

Tailored Resume

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