Principal Scientist, Computational Protein Design

Moderna

Remote
Base: $142,500.00 - $256,500.00; bonus/equity: eli...
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Protein structure and binding interface expertise
Computational protein design methods
Deep learning and structure-based design tools
** Moderna is seeking a Principal Scientist in Computational Protein Design to lead the design of antigens, binders, and antibodies for mRNA therapeutics. The ideal candidate will have extensive experience in computational protein design, a PhD in a relevant field, and a proven track record in vaccine or biologic design. This remote position offers competitive benefits and emphasizes a collaborative company culture focused on innovation. **

Job Summary

  • Serve as the computational protein design lead for vaccine and biologics programs, owning design strategy and technical decision-making.
  • Partner closely with experimental teams by interpreting data from in vitro selection and screening efforts to drive iterative design cycles.
  • The salary range for this role is $142,500.00 - $256,500.00.

Matching Summary

Match Score: 75

** Moderna is seeking a Principal Scientist in Computational Protein Design to lead the design of antigens, binders, and antibodies for mRNA therapeutics. The ideal candidate will have extensive experience in computational protein design, a PhD in a relevant field, and a proven track record in vaccine or biologic design. This remote position offers competitive benefits and emphasizes a collaborative company culture focused on innovation. **

Salary

Base: $142,500.00 - $256,500.00; Bonus/Equity: Eligible for annual discretionary bonus, other incentive compensation, or equity award; Benefits: Best-in-class healthcare, well-being resources, family planning, generous PTO, savings and investment opportunities

Skills & Requirements

Must-have

  • Protein structure and binding interface expertise
  • Computational protein design methods
  • Deep learning and structure-based design tools
  • Design antigens, binders, and antibodies
  • Interpret in vitro selection and screening data

Nice-to-have

  • Motivated by challenging biological problems
  • Shape design standards and mentor designers
  • Collaborative and curious mindset

Key Requirements

  • PhD in related field and 5+ years of experience
  • Extensive post-PhD experience
  • Proven track record of delivering designs
  • Ability to mentor and elevate work

Work Rights

Must be a US person (citizen, permanent resident, asylee, or refugee)

Tailored Resume

Cover Letter