Principal Scientist, Chemical Biology - Discovery Chemistry
Johnson & Johnson UK
Beerse, Belgium
Onsite
Organic synthesis
Chemical biology expertise
Designing and synthesizing chemical biology tools
We are searching for an outstanding, highly skilled, and motivated chemist with excellent organic synthesis and chemical biology expertise to lead and manage our internal chemical biology efforts toward delivering high quality hits, leads, and candidates to Johnson & Johnson's discovery pipeline
Job Summary
We are searching for an outstanding, highly skilled, and motivated chemist with excellent organic synthesis and chemical biology expertise to lead and manage our internal chemical biology efforts toward delivering high quality hits, leads, and candidates to Johnson & Johnson's discovery pipeline.
The successful individual will be responsible for developing chemical probes and tool compounds to enable biological and mechanistic characterization of novel hits/hit series emerging from high-throughput screens and progressing them through stage-gates.
You will be responsible for driving and directing chemical biology functions for drug discovery projects, working in concert with partners in medicinal chemistry, chemoproteomics, disease area biology, and other key functions.
Matching Summary
We are searching for an outstanding, highly skilled, and motivated chemist with excellent organic synthesis and chemical biology expertise to lead and manage our internal chemical biology efforts toward delivering high quality hits, leads, and candidates to Johnson & Johnson's discovery pipeline.
Skills & Requirements
Must-have
organic synthesis
chemical biology expertise
designing and synthesizing chemical biology tools
activity-based protein profiling
photoaffinity labeling
cellular thermal shift assay
Nice-to-have
biopharmaceutical industry experience
targeted protein degradation strategies
scientific contributions
publication record
interdisciplinary work
Key Requirements
PhD in Organic Chemistry, Medicinal Chemistry, or Chemical Biology
5+ years of post-PhD experience in Chemical Biology
Structure-Activity Relationship (SAR)-driven design and synthesis
chemical biology and chemoproteomics methods
chemical biology toward addressing target identification
peer-reviewed first-author publications
latest advances in synthetic chemistry and chemical biology