Novartis is seeking a Principal Scientist to lead the ADPKD Biology initiative, focusing on developing therapies for autosomal dominant polycystic kidney disease. The role requires extensive experience in kidney disease research and expertise in drug discovery, particularly in human-relevant model systems
Job Summary
The Principal Scientist, ADPKD Biology Lead is a senior, lab-embedded scientific leader responsible for shaping and executing ADPKD discovery biology strategy across a portfolio of preclinical programs.
The role will translate insights from human genetics and disease biology into differentiated target hypotheses, lead target triage and validation in advanced human-relevant model systems, including 3D platforms.
US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits.
Matching Summary
Match Score: 85
Novartis is seeking a Principal Scientist to lead the ADPKD Biology initiative, focusing on developing therapies for autosomal dominant polycystic kidney disease. The role requires extensive experience in kidney disease research and expertise in drug discovery, particularly in human-relevant model systems.
Salary
Base: $108,500.00 - $234,000.00; Bonus/Equity: performance-based cash incentive and annual equity awards; Benefits: health, life and disability benefits, 401(k) with company contribution and match, generous time off package
Skills & Requirements
Must-have
ADPKD discovery biology strategy
target triage and validation
human-relevant model systems
3D platforms
decision-grade biology packages
preclinical proof-of-concept
Nice-to-have
external scientific and competitive landscape
emerging targets, modalities, and partnership opportunities
Key Requirements
PhD in nephrology, physiology, pharmacology, molecular biology, cell biology, biochemistry, or a related discipline
8–10+ years of experience in kidney disease research
Meaningful drug discovery experience in a pharmaceutical or biotechnology setting
Proven ability to lead, mentor and develop a high-performing team