Senior Scientist, Protein Sciences

Pfizer

Base: $93,600.00 - $156,000.00; bonus/equity: 12.5...
Protein expression and purification
Integral membrane protein reconstitution
Protein quality control
You will be responsible for expression construct design and purification from bacterial, insect, and mammalian cells, protein quality control, as well as the generation and screening of mutant libraries to generate tools to advance the Pfizer Portfolio of difficult targets including integral membrane proteins and their reconstitution in non-detergent formulations through both functional and binding based HitID screens

Job Summary

  • You will be responsible for expression construct design and purification from bacterial, insect, and mammalian cells, protein quality control, as well as the generation and screening of mutant libraries to generate tools to advance the Pfizer Portfolio of difficult targets including integral membrane proteins and their reconstitution in non-detergent formulations through both functional and binding based HitID screens.
  • With your deep knowledge of the discipline, you will be recognized as a technical expert and a scientific contributor who routinely partners with, and mentors junior colleagues within the department and across therapeutic areas.
  • Your innovation and creativity in developing novel processes and new ideas will be frequently used to drive decision making impact across the portfolio and establish a world-leading Protein Sciences pipeline to serve a world-leading Drug Discovery pipeline.

Matching Summary

You will be responsible for expression construct design and purification from bacterial, insect, and mammalian cells, protein quality control, as well as the generation and screening of mutant libraries to generate tools to advance the Pfizer Portfolio of difficult targets including integral membrane proteins and their reconstitution in non-detergent formulations through both functional and binding based HitID screens.

Salary

Base: $93,600.00 - $156,000.00; Bonus/Equity: 12.5% bonus target; Benefits: Comprehensive benefits package including 401(k), paid time off, medical, dental, and vision coverage

Skills & Requirements

Must-have

  • Protein expression and purification
  • Integral membrane protein reconstitution
  • Protein quality control
  • Mutant library generation and screening
  • Akta purification systems

Nice-to-have

  • Protein structure analysis
  • Phage/yeast/mRNA library generation
  • Protein design for stabilization
  • Binding assay establishment

Key Requirements

  • PhD in Biochemistry, Structural Biology, or related discipline with 1-2 years experience
  • M.S. with 7+ years relevant experience including industry experience
  • Experience with analytical and biophysical methods
  • Experience in expression construct design
  • Experience purifying challenging proteins
  • Experience in integral membrane protein reconstitution
  • Permanent work authorization in the United States

Work Rights

Permanent work authorization required

Tailored Resume

Cover Letter