Postdoctoral Fellow – Ai Enabled Gpcr Structural Biology (cryo-em)

pfizer.ch

Base: $64,600.00 - $107,600.00; bonus/equity: 7.5%...
Gpcr structural biology
Cryo-electron microscopy (cryo-em)
Ai-enabled experimental strategies
Advance next-generation structure-based drug discovery by integrating pharmacology, cryo-EM, and AI–enabled experimental strategies to interrogate dynamic GPCR functional states

Job Summary

  • Advance next-generation structure-based drug discovery by integrating pharmacology, cryo-EM, and AI–enabled experimental strategies to interrogate dynamic GPCR functional states.
  • This role is part of an R&D-funded, AI-focused postdoctoral initiative aimed at enabling structural access to GPCR conformations that are currently difficult or impossible to study using conventional approaches.
  • Collaborate closely with a parallel AI/ML/Computer Science–focused postdoctoral fellow, contributing experimental data and domain insight to an iterative, data-driven model-refinement framework.

Matching Summary

Advance next-generation structure-based drug discovery by integrating pharmacology, cryo-EM, and AI–enabled experimental strategies to interrogate dynamic GPCR functional states.

Salary

Base: $64,600.00 - $107,600.00; Bonus/Equity: 7.5% bonus target; Benefits: Comprehensive and generous benefits package

Skills & Requirements

Must-have

  • GPCR structural biology
  • cryo-electron microscopy (cryo-EM)
  • AI-enabled experimental strategies
  • membrane protein structure determination
  • biochemical and cell-based pharmacology assays

Nice-to-have

  • data-driven model refinement
  • scientific curiosity
  • shaping scientific direction

Key Requirements

  • Ph.D. in Structural Biology, Biochemistry, Pharmacology, Biophysics, Chemical Biology, or related
  • Hands-on experience with cryo-EM workflows
  • Background in membrane-protein or GPCR construct design
  • Experience curating and analyzing structural and functional datasets
  • Permanent work authorization in the United States

Work Rights

Must have permanent work authorization

Tailored Resume

Cover Letter