Senior Research Scientist, Chemical Biology & Proteomics

AstraZeneca

Waltham, MA, US
Base: $116,284.00 - $174,426.00 usd annual; bonus/...
Chemical tools and proteomics technologies
Mass spectrometry-based methods
Covalent screens
Develop and employ chemical tools and proteomics technologies to provide impactful mechanistic insights for drug discovery projects across therapeutic areas

Job Summary

  • Develop and employ chemical tools and proteomics technologies to provide impactful mechanistic insights for drug discovery projects across therapeutic areas.
  • Represent CBP team, communicate with project discipline leads, and contribute to generation of mechanistic hypotheses through interpretation of sophisticated proteomics data.
  • At AstraZeneca, we're dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit.

Matching Summary

Develop and employ chemical tools and proteomics technologies to provide impactful mechanistic insights for drug discovery projects across therapeutic areas.

Salary

Base: $116,284.00 - $174,426.00 USD Annual; Bonus/Equity: short-term incentive bonus opportunity, equity-based long-term incentive program; Benefits: Not specified

Skills & Requirements

Must-have

  • chemical tools and proteomics technologies
  • mass spectrometry-based methods
  • covalent screens
  • target engagement and selectivity profiles
  • drug-induced proteome dynamics
  • post-translational modifications (PTM)
  • quantitative proteomics technologies
  • LC-MS system maintenance

Nice-to-have

  • pre-clinical drug discovery
  • positive, result oriented attitude
  • problem-solving attitude
  • external reputation
  • lifelong learning
  • entrepreneurial spirit

Key Requirements

  • PhD with 2+ years of post-doctoral/industrial experience
  • sample preparation and method development on quantitative mass spectrometry
  • mass spectrometry-based covalent screening
  • IP-MS or chemical probe-based enrichment MS workflows
  • automated processes to analyze large number of samples for MS analysis
  • investigating compound effects under biochemical and cellular settings
  • determining protein abundance and turnover
  • data analysis and clear communication of data interpretation
  • external recognition, presentations, and publications

Work Rights

Not specified

Tailored Resume

Cover Letter