Principal Scientist, Toxicology

Dyne Therapeutics

Waltham, MA, United States
Base: $159,000 - $195,000 usd; bonus/equity: not s...
On-site
Design and execute nonclinical safety plans
Oversee glp-compliant toxicology studies
Manage external cro relationships
Dyne Therapeutics is seeking a Principal Scientist in Toxicology to lead nonclinical safety assessments for their therapeutic programs targeting genetically driven neuromuscular diseases. The ideal candidate should have extensive experience in toxicology, regulatory compliance, and strong leadership skills in a collaborative environment

Job Summary

  • The role involves strategic planning and execution of nonclinical safety plans for investigational antibody oligonucleotide therapeutics targeting muscle diseases.
  • Candidates will serve as the principal contact for external CROs to ensure studies meet quality standards and regulatory guidelines from the FDA and CHMP.
  • The position requires interpreting complex toxicology data and authoring submission-ready documentation for interactions with regulatory authorities.

Matching Summary

Match Score: 85

Dyne Therapeutics is seeking a Principal Scientist in Toxicology to lead nonclinical safety assessments for their therapeutic programs targeting genetically driven neuromuscular diseases. The ideal candidate should have extensive experience in toxicology, regulatory compliance, and strong leadership skills in a collaborative environment.

Salary

Base: $159,000 - $195,000 USD; Bonus/Equity: Not specified; Benefits: Not specified

Skills & Requirements

Must-have

  • Design and execute nonclinical safety plans
  • Oversee GLP-compliant toxicology studies
  • Manage external CRO relationships
  • Interpret toxicology data for submissions
  • Ensure FDA and CHMP regulatory compliance

Nice-to-have

  • Experience with antibody-drug conjugates
  • Expertise in immunotoxicology methods
  • Strong cross-functional communication skills
  • Ability to lead issue-resolution teams
  • Fast-paced collaborative environment experience

Key Requirements

  • PhD or equivalent experience required
  • Minimum 8+ years related experience
  • Board certification preferred
  • Experience with oligonucleotide therapeutics a plus

Work Rights

Not specified

Tailored Resume

Cover Letter