Senior Research Scientist, Chemical Biology & Proteomics

AstraZeneca

Waltham, MA, US
Base: $116,284.00 - $174,426.00 usd annual; bonus/...
**
Phd with 2+ years post-doctoral or industrial experience
Hands-on quantitative mass spectrometry method development
Experience with ip-ms or chemical probe-based enrichment workflows
** AstraZeneca is seeking a Senior Research Scientist to join their Chemical Biology & Proteomics team in Waltham, MA. The ideal candidate will have a PhD and extensive experience in mass spectrometry and proteomics, contributing to drug discovery projects. **

Job Summary

  • The role involves developing chemical tools and proteomics technologies to provide mechanistic insights for drug discovery projects across therapeutic areas.
  • Candidates will design and execute experimental plans to understand target engagement, selectivity profiles, and drug-induced proteome dynamics.
  • AstraZeneca offers an inclusive culture that champions diversity, collaboration, and lifelong learning while empowering employees to push the boundaries of science.

Matching Summary

Match Score: 75

** AstraZeneca is seeking a Senior Research Scientist to join their Chemical Biology & Proteomics team in Waltham, MA. The ideal candidate will have a PhD and extensive experience in mass spectrometry and proteomics, contributing to drug discovery projects. **

Salary

Base: $116,284.00 - $174,426.00 USD Annual; Bonus/Equity: Short-term incentive bonus and equity-based long-term incentive program available; Benefits: Retirement contribution eligibility mentioned

Skills & Requirements

Must-have

  • PhD with 2+ years post-doctoral or industrial experience
  • Hands-on quantitative mass spectrometry method development
  • Experience with IP-MS or chemical probe-based enrichment workflows
  • Expertise in TMT, SILAC, label-free approaches, and DIA
  • Ability to troubleshoot LC-MS systems

Nice-to-have

  • Experience with robotic automation and liquid handling systems
  • Familiarity with targeted proteomics
  • Positive result-oriented problem-solving attitude
  • External reputation through high-impact publications
  • Experience with pre-clinical drug discovery

Key Requirements

  • PhD degree required
  • Minimum 2 years post-doctoral or industrial experience
  • Proven expertise in mass spectrometry-based covalent screening

Work Rights

Not specified

Tailored Resume

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