Front Line Manufacturing Manager - Upstream Bulk Drug Substance - Days

Amgen UK

North Carolina, United States
Base: $106,148.00 - $143,612.00 usd annually; bonu...
Fully remote
Upstream bulk drug substance manufacturing experience
Facility startup and operational readiness support
Cgmp compliance and safety culture enforcement
Amgen UK is seeking a Front Line Manufacturing Manager for their new Upstream Bulk Drug Substance facility in North Carolina. The role involves leading a manufacturing team during the startup and operational phases, ensuring compliance with cGMP standards, while fostering a culture of safety and accountability

Job Summary

  • This role provides frontline leadership to support the design, build, startup, and operational phases of a new Amgen manufacturing facility in North Carolina.
  • The position requires managing cell culture operations including seed train, SUBs, Perfusion, and filtration while ensuring cGMP-compliant execution.
  • Amgen offers a comprehensive benefits package including retirement plans, health coverage, stock-based incentives, and flexible work models.

Matching Summary

Match Score: 85

Amgen UK is seeking a Front Line Manufacturing Manager for their new Upstream Bulk Drug Substance facility in North Carolina. The role involves leading a manufacturing team during the startup and operational phases, ensuring compliance with cGMP standards, while fostering a culture of safety and accountability.

Salary

Base: $106,148.00 - $143,612.00 USD annually; Bonus: Discretionary annual bonus program; Benefits: Comprehensive health, dental, vision, retirement plan, and stock-based incentives

Skills & Requirements

Must-have

  • Upstream bulk drug substance manufacturing experience
  • Facility startup and operational readiness support
  • cGMP compliance and safety culture enforcement
  • 12-hour shift work availability for 24/7 operations
  • Team leadership and performance management skills

Nice-to-have

  • Experience with technology transfer and process implementation
  • Proficiency in MES, DeltaV, Maximo, Veeva, or LIMS systems
  • Background in sustainability and carbon-neutral initiatives
  • Strong conflict resolution and cross-functional collaboration skills

Key Requirements

  • Doctorate OR Master's degree plus 3 years experience OR Bachelor's plus 5 years experience
  • Previous managerial experience directly leading teams or projects
  • Biologics/drug substance manufacturing experience (Upstream) preferred
  • 5+ years cGMP manufacturing experience preferred
  • Ability to work non-standard shifts including holidays and inclement weather

Work Rights

Not specified

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