Associate Principal Scientist, Mammalian Cell Line Engineering And Expression Optimization For Adcs And Bispecifics, With Focus On Non Natural Amino Acid Expression Systems

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Base: $142,377.60 - $213,566.40; bonus/equity: eli...
Not specified (assumed to be hybrid or flexible based on industry standards).
Mammalian cell line engineering
Expression optimization
Non-natural amino acid expression
AstraZeneca is seeking an Associate Principal Scientist specialized in mammalian cell line engineering and expression optimization for antibody-drug conjugates (ADCs) and bispecifics. The role focuses on enhancing non-natural amino acid expression systems to improve product quality and stability, requiring strong leadership, collaboration, and technical expertise in molecular biology and protein expression

Job Summary

  • Provide scientific and strategic leadership for mammalian cell line engineering and expression optimization to accelerate discovery of antibody–drug conjugates (ADCs) and bispecific antibodies.
  • Own the evolution of our nnAA expression system, driving enhancements in vector architecture, genomic context, secretory pathway tuning, and process parameters to improve titer, consistency, and cell‑line stability.
  • AstraZeneca offers an environment where your expertise has tangible impact, with a culture of curiosity, courage, and collaboration enabling us to tackle complex challenges and deliver life‑changing medicines.

Matching Summary

Match Score: 85

AstraZeneca is seeking an Associate Principal Scientist specialized in mammalian cell line engineering and expression optimization for antibody-drug conjugates (ADCs) and bispecifics. The role focuses on enhancing non-natural amino acid expression systems to improve product quality and stability, requiring strong leadership, collaboration, and technical expertise in molecular biology and protein expression.

Salary

Base: $142,377.60 - $213,566.40; Bonus/Equity: eligibility for short-term incentive bonuses, equity-based awards; Benefits: qualified retirement programs, paid time off, health, dental, and vision coverage

Skills & Requirements

Must-have

  • Mammalian cell line engineering
  • Expression optimization
  • Non-natural amino acid expression
  • CHO and HEK platforms
  • Vector and construct design
  • Site-specific genomic integration

Nice-to-have

  • Cross-functional collaboration
  • Automation and high-throughput screening
  • Data integrity and decision packages
  • People leadership and mentoring

Key Requirements

  • PhD with 3+ years industry experience
  • Master’s with 6+ years industry experience
  • Bachelor’s with 8+ years industry experience
  • Proven expertise in mammalian cell line engineering
  • Track record of leading projects and mentoring scientists

Work Rights

Not specified

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